A simple, accurate, validated and reproducible UV-Spectrophotometric method has been developed for the simultaneous estimation of Amlodipine Besylate and Nebivolol in both bulk and tablet formulation. Amlodipine and Nebivolol in combined tablet formulation were estimated by using the multicomponent mode at 361 nm for Amlodipine and 281 nm for Nebivolol in their solution in methanol: water (90:10). The Beer’s law obeyed the concentration range of 10-170µg/ml for both Amlodipine and Nebivolol. Mean recovery of 99.84% for Amlodipine and 99.64% for Nebivolol respectively signifies the accuracy of the method. The methods were validated by accuracy, precision, robustness, ruggedness, LOD & LOQ for both Amlodipine and Nebivolol. The limit of detection for Amlodipine and Nebivolol were 0.565 and0.198.The limit of quantification for Amlodipine and Nebivolol were 1.71 and 0.60. This method can be used for the routine simultaneous estimation of Amlodipine Besylate and Nebivolol in industries and other analytical laboratories.
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